On Wednesday, the health system announced that November 8 is the deadline, including for medical staff, to be fully vaccinated against COVID-19.
Exemptions are possible for religious or medical reasons.
This follows last week's announcement by UnityPoint Health and similar decisions made by health care organizations nationwide.
Genesis Health System President and CEO, Doug Cropper, says the requirement is consistent with the existing policy requiring vaccinations against the flu, and that this serves as "an opportunity for Genesis staff to lead by example and encourage others who have not been vaccinated."
Since December, he says, less than 2.5 percent of nearly 800 patients hospitalized at Genesis with COVID-19 have been fully vaccinated.
Genesis Health System now employs more than 5,000 people in the area.