Kirby Winn from Impact Life says the teams will hold some blood drives at their stadiums, and encourage fans to go to donation centers.
"Summer can be a really challenging time for the blood supply but we also know that during the summer months people love to go to the ballpark and that each of these teams has a great and supportive fan base of community-minded individuals who we hope will respond."
When people make blood donation appointments they can use a special code for the Out for Blood competition to show which team they support.
River Bandits owner Dave Heller says his main goal is to promote blood donation at a time when it's needed more than ever.
"And the only thing I enjoy more than beating Peoria at anything is receiving a trophy for it and displaying it for everybody to see that the Quad Cities is a better community than Peoria."
Blood donors will receive a voucher from their team for a general admission ticket to the final series of the season between the River Bandits and Chiefs, in early September.